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2016 Sikeston Fall Softball Schedule
| Date | Day of Week | Opponent | Location | Time |
| August 20, 2016 | Saturday | Perryville Tournament | Perryville | TBA |
| August 22, 2016 | Monday | Twin Rivers | Away | 4:30 p.m. |
| August 24, 2016 | Wednesday | Ste. Genevieve | Home | 4:30 p.m. |
| August 25, 2016 | Thursday | Poplar Bluff | Away | 4:30 p.m. |
| August 30, 2016 | Tuesday | Perryville | Home | 4:30 p.m. |
| September 6, 2016 | Tuesday | Cape Central | Home | 4:30 p.m. |
| September 7, 2016 | Wednesday | Doniphan | Away | 4:30 p.m. |
| September 8, 2016 | Thursday | East Prairie | Home | 4:30 p.m. |
| September 10, 2016 | Saturday | Potosi Tournament | Potosi | TBA |
| September 12, 2016 | Monday | Notre Dame (Cape Girardeau) | Home | 4:30 p.m. |
| September 14, 2016 | Wednesday | East Prairie | Away | 4:30 p.m. |
| September 15, 2016 | Thursday | Chaffee | Home | 4:30 p.m. |
| September 19, 2016 | Monday | Jackson | Away | 4:30 p.m. |
| September 20, 2016 | Tuesday | Neelyville | Home | 4:30 p.m. |
| September 21, 2016 | Wednesday | Fredericktown | Home | 4:30 p.m. |
| September 22, 2016 | Thursday | Thomas W. Kelly | Away | 4:30 p.m. |
| September 27, 2016 | Tuesday | East Carter County | Home | 4:30 p.m. |
| September 28, 2016 | Wednesday | Saxony Lutheran | Home | 4:30 p.m. |
| September 30-October 1, 2016 | Friday-Saturday | Three Rivers Community College (TRCC) Invitational Tournament | Poplar Bluff | TBA |
| October 3, 2016 | Monday | Naylor | Away | 4:30 p.m. |